We are pleased to announce that Dr. Yong Zhao collaborated with his colleagues Dr. Robert Korngold’s group at the Center For Discovery and Innovation (CDI) of Hackensack Meridian Health, published a new manuscript in Transplantation and Cellular Therapy, (the official journal of the American Society for Transplantation and Cellular Therapy), titled “Cord Blood Derived-Multipotent Stem Cells Ameliorate In-Vitro/In-Vivo Alloreactive Responses and this Effect is Associated with Exosomal Microvesicles in Vitro”.
Animal studies demonstrated that CB-SC ameliorated the development of GvHD responses in a xenogeneic human peripheral blood mononuclear cells (PBMC)-induced NSG mouse model. These results indicate that CB-SC can directly and indirectly attenuate alloreactive CD4 T cell activation and proliferation in vitro with a potentially related exosomal microvesicles (EV) mode of action and may have potential utilization as a cell therapy to control donor T cell mediated GvHD responses in vivo.